| 1 | ==BBMRI omics Hands-on Course=== |
| 2 | |
| 3 | date: March 31, 2017 |
| 4 | Location: SURFsara, Utrech |
| 5 | url: https://www.bbmri.nl/event/bbmri-omics-introduction-and-hands-on-application/=== |
| 6 | |
| 7 | ==Program==: |
| 8 | |
| 9 | 10:00-10:30 Introduction to available omics data within BBMRI-omics.nl. Description of RNA-seq, 450k methylation, metabolomics, imputed genotypes, phenotypes and technical covariates. Data location and access. (Rick Jansen) |
| 10 | |
| 11 | 10.30-11.15: Introduction to R package BIOSRutils. How to use BIOSRutils for filtering and QC, and finally run EWAS and TWAS (Maarten van Iterson) |
| 12 | |
| 13 | 11.15-12.15: Practicum (Maarten van Iterson) |
| 14 | |
| 15 | 12.15-13.15: Lunch (demo: using BBMRI-Omics.nl online atlases (Jan-Bert van Klinken)) |
| 16 | |
| 17 | 13.15-13.45: Joost Verlouw: QTL lookup of GWAS hits. Take the SNP hits from a recent GWAS, extract corresponding BIOS genotype data, run association with full Methylation, Expression and Metabolomics data sets. |
| 18 | |
| 19 | 13.45-14.45: Practicum (Joost Verlouw) |
| 20 | |
| 21 | 14.45-15.15- Tea break |
| 22 | |
| 23 | 15:15-15:45: Introduction to the Brainshake 1H-NMR metabolomics platform (Marian Beekman) |
| 24 | |
| 25 | 15:45-16.30: Practicum. Analyzing Metabolomics data (Koen Dekker) |
| 26 | |
| 27 | 16:30-17:00: Allele specific expression (Niek de Klein/Freerk van Dijk) |
| 28 | 17:00-17:45: Practicum (Niek de Klein/Freerk van Dijk)) |
| 29 | |
| 30 | 18:00 Drinks |
| 31 | |
| 32 | ==Practicum guidelines and exercises== |
| 33 | |