Changes between Version 43 and Version 44 of BIOS_start-


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Timestamp:
Mar 16, 2021 6:11:44 AM (4 years ago)
Author:
Leon Mei
Comment:

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  • BIOS_start-

    v43 v44  
    66The advent of the genome-wide association study (GWAS) led to the successful identification of thousands of variants that are robustly associated with complex disease phenotypes. Dutch biobanks played a substantial role in these discoveries. For most of these variants, however, the mechanisms through which they contribute to these phenotypes remain unknown. The BIOS Consortium applies a functional genomics approach that integrates genome-wide genetic data with data on the epigenome and transcriptome to elucidate these mechanisms. Over 4000 samples from BBMRI-NL biobanks with in-depth information on disease phenotypes and GWAS data are being enriched with RNA-sequencing and genome-wide DNA methylation data. The same is true for samples with whole-genome sequencing data from GoNL. This unique data infrastructure provides a powerful platform to evaluate key questions in integrative omics from establishing comprehensive eQTL and meQTL catalogues to linking molecular pathways across omics levels to phenotypic outcomes.
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    8 See also [https://www.bbmri.nl/on_offer/bios/ our BBMRI website]
     8See also [https://www.bbmri.nl/services/samples-images-data/integrative-omics-data-set our BBMRI website]
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    1010'''Note:''' Read [wiki:BIOS_Wiki Using this wiki] before making changes to these pages.